BDBM50510046 CHEMBL4440380

SMILES: Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc2CCNc2c1

InChI Key: InChIKey=CIUALEFWGGLUHY-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50510046   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Acid-sensing ion channel 1 (Mus musculus)	BDBM50510046 (CHEMBL4440380) Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc2CCNc2c1 Show InChI InChI=1S/C19H18FN3/c1-12-19(15-3-6-16(20)7-4-15)13(2)23(22-12)17-8-5-14-9-10-21-18(14)11-17/h3-8,11,21H,9-10H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Promidis Curated by ChEMBL					Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay				ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591
					More data for this Ligand-Target Pair
Acid-sensing ion channel 2 (Mus musculus)	BDBM50510046 (CHEMBL4440380) Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc2CCNc2c1 Show InChI InChI=1S/C19H18FN3/c1-12-19(15-3-6-16(20)7-4-15)13(2)23(22-12)17-8-5-14-9-10-21-18(14)11-17/h3-8,11,21H,9-10H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Promidis Curated by ChEMBL					Assay Description Inhibition of pH 5.5-stimulated mouse ASIC2a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay				ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591
					More data for this Ligand-Target Pair
Acid-sensing ion channel 2 (Mus musculus)	BDBM50510046 (CHEMBL4440380) Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc2CCNc2c1 Show InChI InChI=1S/C19H18FN3/c1-12-19(15-3-6-16(20)7-4-15)13(2)23(22-12)17-8-5-14-9-10-21-18(14)11-17/h3-8,11,21H,9-10H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Promidis Curated by ChEMBL					Assay Description Inhibition of pH 6.25-stimulated mouse ASIC1a/2a heterodimer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence...				ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591
					More data for this Ligand-Target Pair