null
SMILES: [H][C@@]12CC=CC[C@]1([H])C(=NN(C(C)C)C2=O)c1ccc(OC)c(c1)C#CC(N)=O
InChI Key: InChIKey=KIILUOSGHLGYRG-DLBZAZTESA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human)) | BDBM50512753![]() (CHEMBL4463356) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | 316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Amsterdam Curated by ChEMBL | Assay Description Inhibition of human PDE4B catalytic domain using cAMP as substrate incubated for 20 mins by PDELight HTS cAMP phosphodiesterase Kit based luminometry | Bioorg Med Chem 27: 4013-4029 (2019) Article DOI: 10.1016/j.bmc.2019.06.026 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50512753![]() (CHEMBL4463356) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | 501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei PDEB1 catalytic domain using cAMP as substrate incubated for 20 mins by PDELight HTS cAMP phosphodiesterase Kit base... | Bioorg Med Chem 27: 4013-4029 (2019) Article DOI: 10.1016/j.bmc.2019.06.026 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human)) | BDBM50512753![]() (CHEMBL4463356) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Amsterdam Curated by ChEMBL | Assay Description Binding affinity to human PDE4D assessed as dissociation constant treated for 60 secs measured for 300 secs by SPR assay | Bioorg Med Chem 27: 4013-4029 (2019) Article DOI: 10.1016/j.bmc.2019.06.026 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50512753![]() (CHEMBL4463356) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Amsterdam Curated by ChEMBL | Assay Description Binding affinity to Trypanosoma brucei PDEB1 assessed as dissociation constant treated for 60 secs measured for 300 secs by SPR assay | Bioorg Med Chem 27: 4013-4029 (2019) Article DOI: 10.1016/j.bmc.2019.06.026 | |||||||||||
More data for this Ligand-Target Pair |