null

SMILES: O=C(C1CCN(CC1)C(=O)c1cc[nH]n1)N1N=CCC1c1ccccc1

InChI Key: InChIKey=GAEYWYAKLLSDJH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50513047   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50513047 (CHEMBL4583157) Show SMILES O=C(C1CCN(CC1)C(=O)c1cc[nH]n1)N1N=CCC1c1ccccc1 |c:18| Show InChI InChI=1S/C19H21N5O2/c25-18(24-17(7-11-21-24)14-4-2-1-3-5-14)15-8-12-23(13-9-15)19(26)16-6-10-20-22-16/h1-6,10-11,15,17H,7-9,12-13H2,(H,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necroptosis measured after 24 hrs by cell titer-glo luminesc...				J Med Chem 62: 5096-5110 (2019) Article DOI: 10.1021/acs.jmedchem.9b00318
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50513047 (CHEMBL4583157) Show SMILES O=C(C1CCN(CC1)C(=O)c1cc[nH]n1)N1N=CCC1c1ccccc1 |c:18| Show InChI InChI=1S/C19H21N5O2/c25-18(24-17(7-11-21-24)14-4-2-1-3-5-14)15-8-12-23(13-9-15)19(26)16-6-10-20-22-16/h1-6,10-11,15,17H,7-9,12-13H2,(H,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)-16...				J Med Chem 62: 5096-5110 (2019) Article DOI: 10.1021/acs.jmedchem.9b00318
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50513047 (CHEMBL4583157) Show SMILES O=C(C1CCN(CC1)C(=O)c1cc[nH]n1)N1N=CCC1c1ccccc1 |c:18| Show InChI InChI=1S/C19H21N5O2/c25-18(24-17(7-11-21-24)14-4-2-1-3-5-14)15-8-12-23(13-9-15)19(26)16-6-10-20-22-16/h1-6,10-11,15,17H,7-9,12-13H2,(H,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of human GST/His-tagged RIP1 (1 to 375 residues) expressed in baculovirus expression system assessed as reduction in autophosphorylation m...				J Med Chem 62: 5096-5110 (2019) Article DOI: 10.1021/acs.jmedchem.9b00318
					More data for this Ligand-Target Pair