BDBM50513098 CHEMBL4581717

SMILES: COc1ccccc1Cc1cc(C)nn(CC(=O)Nc2ccccc2C#N)c1=O

InChI Key: InChIKey=VSCGDEDLDDOLCU-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50513098   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
fMet-Leu-Phe receptor (Homo sapiens (Human))	BDBM50513098 (CHEMBL4581717) Show SMILES COc1ccccc1Cc1cc(C)nn(CC(=O)Nc2ccccc2C#N)c1=O Show InChI InChI=1S/C22H20N4O3/c1-15-11-18(12-16-7-4-6-10-20(16)29-2)22(28)26(25-15)14-21(27)24-19-9-5-3-8-17(19)13-23/h3-11H,12,14H2,1-2H3,(H,24,27)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	<1.00E+5	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphasc...				J Med Chem 62: 5242-5248 (2019) Article DOI: 10.1021/acs.jmedchem.8b01912
					More data for this Ligand-Target Pair
fMet-Leu-Phe receptor (Homo sapiens (Human))	BDBM50513098 (CHEMBL4581717) Show SMILES COc1ccccc1Cc1cc(C)nn(CC(=O)Nc2ccccc2C#N)c1=O Show InChI InChI=1S/C22H20N4O3/c1-15-11-18(12-16-7-4-6-10-20(16)29-2)22(28)26(25-15)14-21(27)24-19-9-5-3-8-17(19)13-23/h3-11H,12,14H2,1-2H3,(H,24,27)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	<1.00E+5	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence...				J Med Chem 62: 5242-5248 (2019) Article DOI: 10.1021/acs.jmedchem.8b01912
					More data for this Ligand-Target Pair