BDBM50513116 CHEMBL4514037

SMILES: COc1ccccc1Cc1cc(C)nn(CC(=O)Nc2ccc(OC(F)(F)F)cc2)c1=O

InChI Key: InChIKey=DXROAFDKCSRXKC-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50513116   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
fMet-Leu-Phe receptor (Homo sapiens (Human))	BDBM50513116 (CHEMBL4514037) Show SMILES COc1ccccc1Cc1cc(C)nn(CC(=O)Nc2ccc(OC(F)(F)F)cc2)c1=O Show InChI InChI=1S/C22H20F3N3O4/c1-14-11-16(12-15-5-3-4-6-19(15)31-2)21(30)28(27-14)13-20(29)26-17-7-9-18(10-8-17)32-22(23,24)25/h3-11H,12-13H2,1-2H3,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	<1.00E+5	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphasc...				J Med Chem 62: 5242-5248 (2019) Article DOI: 10.1021/acs.jmedchem.8b01912
					More data for this Ligand-Target Pair
fMet-Leu-Phe receptor (Homo sapiens (Human))	BDBM50513116 (CHEMBL4514037) Show SMILES COc1ccccc1Cc1cc(C)nn(CC(=O)Nc2ccc(OC(F)(F)F)cc2)c1=O Show InChI InChI=1S/C22H20F3N3O4/c1-14-11-16(12-15-5-3-4-6-19(15)31-2)21(30)28(27-14)13-20(29)26-17-7-9-18(10-8-17)32-22(23,24)25/h3-11H,12-13H2,1-2H3,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	<1.00E+5	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence...				J Med Chem 62: 5242-5248 (2019) Article DOI: 10.1021/acs.jmedchem.8b01912
					More data for this Ligand-Target Pair