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SMILES: FCCc1ccc(cc1)-c1ccc(s1)-c1cn(nn1)[C@H]1CN2CCC1CC2

InChI Key: InChIKey=CFUIJXFYQSPAMV-IBGZPJMESA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50513608   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50513608
PNG
(CHEMBL4457405)
Show SMILES FCCc1ccc(cc1)-c1ccc(s1)-c1cn(nn1)[C@H]1CN2CCC1CC2 |r,wU:19.21,(66.4,-1.58,;65.15,-2.49,;63.74,-1.86,;62.5,-2.77,;62.66,-4.3,;61.42,-5.21,;60.01,-4.57,;59.85,-3.05,;61.08,-2.15,;58.77,-5.48,;58.77,-7.01,;57.31,-7.49,;56.4,-6.25,;57.31,-5.01,;54.87,-6.25,;53.8,-7.43,;52.35,-6.78,;52.52,-5.2,;54.08,-4.88,;50.97,-7.57,;50.97,-9.16,;49.6,-9.95,;48.23,-9.16,;48.23,-7.57,;49.6,-6.77,;49.99,-8.14,;49.12,-8.61,)|
Show InChI InChI=1S/C21H23FN4S/c22-10-7-15-1-3-17(4-2-15)20-5-6-21(27-20)18-13-26(24-23-18)19-14-25-11-8-16(19)9-12-25/h1-6,13,16,19H,7-12,14H2/t19-/m0/s1
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 157n/an/an/an/an/an/an/an/a



Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Displacement of [125I]-alpha-bungarotoxin from alpha7 nAChR in Wistar rat brain membrane incubated for 3 hrs by gamma counting analysis

Eur J Med Chem 179: 449-469 (2019)


Article DOI: 10.1016/j.ejmech.2019.06.049
More data for this
Ligand-Target Pair