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BDBM50514124 CHEMBL4443220

SMILES: Fc1cccc(Cl)c1C(=O)Nc1ccc(Oc2cc(I)cc(c2)C(F)(F)F)cc1

InChI Key: InChIKey=ARJZDZRUKYHUHE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50514124   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Toll-like receptor 8


(Homo sapiens (Human))		BDBM50514124
PNG
(CHEMBL4443220)
Show SMILES Fc1cccc(Cl)c1C(=O)Nc1ccc(Oc2cc(I)cc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H11ClF4INO2/c21-16-2-1-3-17(22)18(16)19(28)27-13-4-6-14(7-5-13)29-15-9-11(20(23,24)25)8-12(26)10-15/h1-10H,(H,27,28)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



University of Colorado Boulder

Curated by ChEMBL


Assay Description
Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...

J Med Chem 62: 10221-10244 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01201
More data for this
Ligand-Target Pair