BDBM50514126 CHEMBL4553003

SMILES: Fc1cccc(Br)c1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1

InChI Key: InChIKey=BHSMBMUGBJTRRU-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50514126   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50514126 (CHEMBL4553003) Show SMILES Fc1cccc(Br)c1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C21H11BrF7NO2/c22-16-2-1-3-17(23)18(16)19(31)30-13-4-6-14(7-5-13)32-15-9-11(20(24,25)26)8-12(10-15)21(27,28)29/h1-10H,(H,30,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514126 (CHEMBL4553003) Show SMILES Fc1cccc(Br)c1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C21H11BrF7NO2/c22-16-2-1-3-17(23)18(16)19(31)30-13-4-6-14(7-5-13)32-15-9-11(20(24,25)26)8-12(10-15)21(27,28)29/h1-10H,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201
					More data for this Ligand-Target Pair