BDBM50514132 CHEMBL4460468

SMILES: Fc1cccc(Cl)c1C(=O)Nc1ccc(Oc2cc(Br)cc(c2)C(F)(F)F)cc1

InChI Key: InChIKey=LGGHYBAKEQQAGB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50514132   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514132 (CHEMBL4460468) Show SMILES Fc1cccc(Cl)c1C(=O)Nc1ccc(Oc2cc(Br)cc(c2)C(F)(F)F)cc1 Show InChI InChI=1S/C20H11BrClF4NO2/c21-12-8-11(20(24,25)26)9-15(10-12)29-14-6-4-13(5-7-14)27-19(28)18-16(22)2-1-3-17(18)23/h1-10H,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201
					More data for this Ligand-Target Pair