BDBM50514142 CHEMBL4475509

SMILES: FC(F)(F)c1cc(Oc2ccc(NC(=O)c3ccc4nc[nH]c4c3)cc2)cc(c1)C(F)(F)F

InChI Key: InChIKey=CQFCVDUTLCPVNP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50514142   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50514142 (CHEMBL4475509) Show SMILES FC(F)(F)c1cc(Oc2ccc(NC(=O)c3ccc4nc[nH]c4c3)cc2)cc(c1)C(F)(F)F Show InChI InChI=1S/C22H13F6N3O2/c23-21(24,25)13-8-14(22(26,27)28)10-17(9-13)33-16-4-2-15(3-5-16)31-20(32)12-1-6-18-19(7-12)30-11-29-18/h1-11H,(H,29,30)(H,31,32)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201
					More data for this Ligand-Target Pair