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BDBM50514149 CHEMBL4524477

SMILES: Fc1cccc(Cl)c1NC(=O)c1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1

InChI Key: InChIKey=LUISIXQGSQDESL-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50514149   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Toll-like receptor 7


(Homo sapiens (Human))		BDBM50514149
PNG
(CHEMBL4524477)
Show SMILES Fc1cccc(Cl)c1NC(=O)c1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1
Show InChI InChI=1S/C21H11ClF7NO2/c22-16-2-1-3-17(23)18(16)30-19(31)11-4-6-14(7-5-11)32-15-9-12(20(24,25)26)8-13(10-15)21(27,28)29/h1-10H,(H,30,31)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.10E+3n/an/an/an/an/an/a



University of Colorado Boulder

Curated by ChEMBL


Assay Description
Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in resiquimod-induced NFkappaB production at 1.5 to 5 uM incubated for 16 hr...

J Med Chem 62: 10221-10244 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01201
More data for this
Ligand-Target Pair