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BDBM50514800 CHEMBL4449343

SMILES: CCCc1nnc(SC)n1-c1ccc(Cl)cc1Cl

InChI Key: InChIKey=ZTIYCBDSNPPTFM-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50514800   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Toll-like receptor 8


(Homo sapiens (Human))		BDBM50514800
PNG
(CHEMBL4449343)
Show SMILES CCCc1nnc(SC)n1-c1ccc(Cl)cc1Cl |(5.01,-12.3,;6.49,-11.89,;6.89,-10.4,;8.38,-9.99,;8.92,-8.56,;10.43,-8.62,;10.85,-10.1,;12.29,-10.62,;13.46,-9.64,;9.57,-10.95,;9.57,-12.49,;8.24,-13.26,;8.23,-14.8,;9.57,-15.57,;9.57,-17.1,;10.89,-14.8,;10.9,-13.26,;12.24,-12.48,)|
Show InChI InChI=1S/C12H13Cl2N3S/c1-3-4-11-15-16-12(18-2)17(11)10-6-5-8(13)7-9(10)14/h5-7H,3-4H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 630n/an/an/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Inhibition of human TLR8 expressed in HEK-Blue cells assessed as inhibition of R848-induced NF-kappaB activation measured after 24 hrs by quanti-blue...

J Med Chem 63: 4117-4132 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02128
More data for this
Ligand-Target Pair