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BDBM50514801 CHEMBL4473196

SMILES: COCCCc1nnc(SC)n1-c1ccc(Cl)cc1Cl

InChI Key: InChIKey=UQDISJVOMDOFOE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50514801   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Toll-like receptor 8


(Homo sapiens (Human))		BDBM50514801
PNG
(CHEMBL4473196)
Show SMILES COCCCc1nnc(SC)n1-c1ccc(Cl)cc1Cl |(15.11,-6.31,;13.63,-5.89,;12.53,-6.97,;11.05,-6.55,;9.94,-7.62,;8.46,-7.21,;7.93,-5.76,;6.39,-5.82,;5.97,-7.3,;4.53,-7.84,;3.34,-6.85,;7.25,-8.16,;7.31,-9.7,;6.01,-10.52,;6.07,-12.06,;7.43,-12.78,;7.5,-14.32,;8.74,-11.95,;8.68,-10.42,;9.98,-9.59,)|
Show InChI InChI=1S/C13H15Cl2N3OS/c1-19-7-3-4-12-16-17-13(20-2)18(12)11-6-5-9(14)8-10(11)15/h5-6,8H,3-4,7H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.18E+3n/an/an/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Inhibition of human TLR8 expressed in HEK-Blue cells assessed as inhibition of R848-induced NF-kappaB activation measured after 24 hrs by quanti-blue...

J Med Chem 63: 4117-4132 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02128
More data for this
Ligand-Target Pair