BDBM50514803 CHEMBL4547071

SMILES: CSc1nnc(CCCO)n1-c1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=OTBKUUBYGBXYER-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50514803   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514803 (CHEMBL4547071) Show SMILES CSc1nnc(CCCO)n1-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C13H14F3N3OS/c1-21-12-18-17-11(3-2-8-20)19(12)10-6-4-9(5-7-10)13(14,15)16/h4-7,20H,2-3,8H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.84E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK-Blue cells assessed as inhibition of R848-induced NF-kappaB activation measured after 24 hrs by quanti-blue...				J Med Chem 63: 4117-4132 (2020) Article DOI: 10.1021/acs.jmedchem.9b02128
					More data for this Ligand-Target Pair