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BDBM50516628 CHEMBL4522547

SMILES: CC(c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CCC(C(C)C1)N1CCCCC1

InChI Key: InChIKey=CMQWXPKMVHCRIK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50516628   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50516628
PNG
(CHEMBL4522547)
Show SMILES CC(c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CCC(C(C)C1)N1CCCCC1
Show InChI InChI=1S/C25H32Cl2N6/c1-16-15-32(12-9-22(16)31-10-5-4-6-11-31)23-14-28-24-17(2)30-33(25(24)29-23)18(3)20-8-7-19(26)13-21(20)27/h7-8,13-14,16,18,22H,4-6,9-12,15H2,1-3H3
UniProtKB/SwissProt
UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 126n/an/an/an/an/an/a



RAPT Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...

J Med Chem 62: 6190-6213 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00506
More data for this
Ligand-Target Pair