BDBM50517429 CHEMBL4436404

SMILES: C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(CC1CC1)c2=O

InChI Key: InChIKey=CBXHYUCLQVWOJZ-GFCCVEGCSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50517429   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50517429 (CHEMBL4436404) Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(CC1CC1)c2=O |r| Show InChI InChI=1S/C23H25N5O2/c1-12-18-16(20(29)24-12)10-17(25-18)14-4-3-5-15-19(14)26-22(27-23(2)8-9-23)28(21(15)30)11-13-6-7-13/h3-5,10,12-13,25H,6-9,11H2,1-2H3,(H,24,29)(H,26,27)/t12-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...				J Med Chem 62: 1523-1540 (2019) Article DOI: 10.1021/acs.jmedchem.8b01733
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50517429 (CHEMBL4436404) Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(CC1CC1)c2=O |r| Show InChI InChI=1S/C23H25N5O2/c1-12-18-16(20(29)24-12)10-17(25-18)14-4-3-5-15-19(14)26-22(27-23(2)8-9-23)28(21(15)30)11-13-6-7-13/h3-5,10,12-13,25H,6-9,11H2,1-2H3,(H,24,29)(H,26,27)/t12-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.0600	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...				J Med Chem 62: 1523-1540 (2019) Article DOI: 10.1021/acs.jmedchem.8b01733
					More data for this Ligand-Target Pair