null

SMILES: C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(CC1(O)CC1)c2=O

InChI Key: InChIKey=AWSQCMGUEHCTJL-GFCCVEGCSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50517430   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50517430 (CHEMBL4446411) Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(CC1(O)CC1)c2=O |r| Show InChI InChI=1S/C23H25N5O3/c1-12-17-15(19(29)24-12)10-16(25-17)13-4-3-5-14-18(13)26-21(27-22(2)6-7-22)28(20(14)30)11-23(31)8-9-23/h3-5,10,12,25,31H,6-9,11H2,1-2H3,(H,24,29)(H,26,27)/t12-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...				J Med Chem 62: 1523-1540 (2019) Article DOI: 10.1021/acs.jmedchem.8b01733 BindingDB Entry DOI: 10.7270/Q25X2D97
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50517430 (CHEMBL4446411) Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(CC1(O)CC1)c2=O |r| Show InChI InChI=1S/C23H25N5O3/c1-12-17-15(19(29)24-12)10-16(25-17)13-4-3-5-14-18(13)26-21(27-22(2)6-7-22)28(20(14)30)11-23(31)8-9-23/h3-5,10,12,25,31H,6-9,11H2,1-2H3,(H,24,29)(H,26,27)/t12-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...				J Med Chem 62: 1523-1540 (2019) Article DOI: 10.1021/acs.jmedchem.8b01733 BindingDB Entry DOI: 10.7270/Q25X2D97
					More data for this Ligand-Target Pair