BDBM50517566 CHEMBL4436946

SMILES: ONC(=O)c1ccc(CN2N=CC=C3Sc4ccccc4N=C23)cc1

InChI Key: InChIKey=LNRRJZSSJOCAAI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50517566   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50517566 (CHEMBL4436946) Show SMILES ONC(=O)c1ccc(CN2N=CC=C3Sc4ccccc4N=C23)cc1 |c:10,t:12,22| Show InChI InChI=1S/C18H14N4O2S/c23-18(21-24)13-7-5-12(6-8-13)11-22-17-16(9-10-19-22)25-15-4-2-1-3-14(15)20-17/h1-10,24H,11H2,(H,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Ludwig-Maximilians University Munich Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged human HDAC6 expressed in baculovirus expression system using fluorogenic ZMAL as substrate incubated ...				J Med Chem 62: 1138-1166 (2019) Article DOI: 10.1021/acs.jmedchem.8b01090
					More data for this Ligand-Target Pair