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SMILES: Cc1c(OCc2cccc(Br)c2)ccc2cc(C(N)=O)c(=O)oc12

InChI Key: InChIKey=PTDWWMKADHDWQL-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50519175   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Chloride anion exchanger


(Mus musculus)		BDBM50519175
PNG
(CHEMBL4593314)
Show SMILES Cc1c(OCc2cccc(Br)c2)ccc2cc(C(N)=O)c(=O)oc12
Show InChI InChI=1S/C18H14BrNO4/c1-10-15(23-9-11-3-2-4-13(19)7-11)6-5-12-8-14(17(20)21)18(22)24-16(10)12/h2-8H,9H2,1H3,(H2,20,21)
MMDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of mouse slc26a3 expressed in FRT cells co-expressing EYFP-H148Q/I152L/F46L assessed as reduction in protein-mediated chloride/iodide exch...

J Med Chem 62: 8330-8337 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01192
More data for this
Ligand-Target Pair