null

SMILES: CNC(=O)c1cnc(Nc2ccc(cn2)C#N)cc1Nc1cccc(-c2ncn(C)n2)c1OC

InChI Key: InChIKey=IIRJKMJZLJRGQN-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50519537   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
1,3-beta-glucan synthase component GSC2 (Saccharomyces cerevisiae)	BDBM50519537 (CHEMBL4469750) Show SMILES CNC(=O)c1cnc(Nc2ccc(cn2)C#N)cc1Nc1cccc(-c2ncn(C)n2)c1OC Show InChI InChI=1S/C23H21N9O2/c1-25-23(33)16-12-27-20(30-19-8-7-14(10-24)11-26-19)9-18(16)29-17-6-4-5-15(21(17)34-3)22-28-13-32(2)31-22/h4-9,11-13H,1-3H3,(H,25,33)(H2,26,27,29,30)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human ERG by in vitro patch clamp method				J Med Chem 62: 8973-8995 (2019) Article DOI: 10.1021/acs.jmedchem.9b00444
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50519537 (CHEMBL4469750) Show SMILES CNC(=O)c1cnc(Nc2ccc(cn2)C#N)cc1Nc1cccc(-c2ncn(C)n2)c1OC Show InChI InChI=1S/C23H21N9O2/c1-25-23(33)16-12-27-20(30-19-8-7-14(10-24)11-26-19)9-18(16)29-17-6-4-5-15(21(17)34-3)22-28-13-32(2)31-22/h4-9,11-13H,1-3H3,(H,25,33)(H2,26,27,29,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of TYK2 in human whole blood assessed as decrease in IFNalpha-induced STAT5 phosphorylation preincubated for 1 hr followed by stimulation ...				J Med Chem 62: 8973-8995 (2019) Article DOI: 10.1021/acs.jmedchem.9b00444
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM50519537 (CHEMBL4469750) Show SMILES CNC(=O)c1cnc(Nc2ccc(cn2)C#N)cc1Nc1cccc(-c2ncn(C)n2)c1OC Show InChI InChI=1S/C23H21N9O2/c1-25-23(33)16-12-27-20(30-19-8-7-14(10-24)11-26-19)9-18(16)29-17-6-4-5-15(21(17)34-3)22-28-13-32(2)31-22/h4-9,11-13H,1-3H3,(H,25,33)(H2,26,27,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assay				J Med Chem 62: 8973-8995 (2019) Article DOI: 10.1021/acs.jmedchem.9b00444
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [5-1181] (Mus musculus)	BDBM50519537 (CHEMBL4469750) Show SMILES CNC(=O)c1cnc(Nc2ccc(cn2)C#N)cc1Nc1cccc(-c2ncn(C)n2)c1OC Show InChI InChI=1S/C23H21N9O2/c1-25-23(33)16-12-27-20(30-19-8-7-14(10-24)11-26-19)9-18(16)29-17-6-4-5-15(21(17)34-3)22-28-13-32(2)31-22/h4-9,11-13H,1-3H3,(H,25,33)(H2,26,27,29,30)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of TYK2 in mouse whole blood assessed as decrease in IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by stimulation ...				J Med Chem 62: 8973-8995 (2019) Article DOI: 10.1021/acs.jmedchem.9b00444
					More data for this Ligand-Target Pair