BDBM50519616 CHEMBL4449176
SMILES: OC(=O)c1ccc2OC[C@]3(CCc4cc(Cl)ccc34)CN(CC3CCC3)c2c1
InChI Key: InChIKey=YLXRDIJLTBHLLJ-QHCPKHFHSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50519616![]() (CHEMBL4449176) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandie Univiversit� Curated by ChEMBL | Assay Description Inhibition of TAMRA-labeled BIM BH3 peptide binding to human Mcl1 (171 to 327 residues) incubated for 120 mins by fluorescence polarization | J Med Chem 63: 928-943 (2020) Article DOI: 10.1021/acs.jmedchem.9b00983 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |