Found 5 hits for monomerid = 50520252 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
MAP kinase-interacting serine/threonine-protein kinase 1/2
(Homo sapiens (Human)) | BDBM50520252
(CHEMBL4440223)Show SMILES CC(C)Oc1cc(ccc1C(N)=O)-c1cncc(c1)-c1cnn(C)c1C Show InChI InChI=1S/C20H22N4O2/c1-12(2)26-19-8-14(5-6-17(19)20(21)25)15-7-16(10-22-9-15)18-11-23-24(4)13(18)3/h5-12H,1-4H3,(H2,21,25) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
A*STAR
Curated by ChEMBL
| Assay Description
Inhibition of MNK1/MNK2 in human HeLa cells overexpressing eIF4E assessed as reduction in eIF4E phosphorylation at Ser209 residue after 2 hrs by Alph... |
J Med Chem 63: 621-637 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01582 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50520252
(CHEMBL4440223)Show SMILES CC(C)Oc1cc(ccc1C(N)=O)-c1cncc(c1)-c1cnn(C)c1C Show InChI InChI=1S/C20H22N4O2/c1-12(2)26-19-8-14(5-6-17(19)20(21)25)15-7-16(10-22-9-15)18-11-23-24(4)13(18)3/h5-12H,1-4H3,(H2,21,25) | PDB
UniProtKB/SwissProt
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
A*STAR
Curated by ChEMBL
| Assay Description
Inhibition of CYP2D6 (unknown origin) |
J Med Chem 63: 621-637 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01582 |
More data for this
Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50520252
(CHEMBL4440223)Show SMILES CC(C)Oc1cc(ccc1C(N)=O)-c1cncc(c1)-c1cnn(C)c1C Show InChI InChI=1S/C20H22N4O2/c1-12(2)26-19-8-14(5-6-17(19)20(21)25)15-7-16(10-22-9-15)18-11-23-24(4)13(18)3/h5-12H,1-4H3,(H2,21,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
A*STAR
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged MNK2 (unknown origin) (72 to 385 residues) expressed in Escherichia coli BL21 (DE3) cells using 5-FAM-TATKSGSTTKN... |
J Med Chem 63: 621-637 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01582 |
More data for this
Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50520252
(CHEMBL4440223)Show SMILES CC(C)Oc1cc(ccc1C(N)=O)-c1cncc(c1)-c1cnn(C)c1C Show InChI InChI=1S/C20H22N4O2/c1-12(2)26-19-8-14(5-6-17(19)20(21)25)15-7-16(10-22-9-15)18-11-23-24(4)13(18)3/h5-12H,1-4H3,(H2,21,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
A*STAR
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged MNK1 (unknown origin) (37 to 341 residues) expressed in Escherichia coli BL21 (DE3) cells using 5-FAM-TATKSGSTTKN... |
J Med Chem 63: 621-637 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01582 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50520252
(CHEMBL4440223)Show SMILES CC(C)Oc1cc(ccc1C(N)=O)-c1cncc(c1)-c1cnn(C)c1C Show InChI InChI=1S/C20H22N4O2/c1-12(2)26-19-8-14(5-6-17(19)20(21)25)15-7-16(10-22-9-15)18-11-23-24(4)13(18)3/h5-12H,1-4H3,(H2,21,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
A*STAR
Curated by ChEMBL
| Assay Description
Inhibition of CYP3A4 (unknown origin) |
J Med Chem 63: 621-637 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01582 |
More data for this
Ligand-Target Pair | |
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