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SMILES: Cn1cccc1-c1ccc(-c2ccc(-c3ccc(-c4ccccc4)n3C)n2C)n1C

InChI Key: InChIKey=QRXWBYLQXGFCRY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50520945   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proprotein convertase subtilisin/kexin type 9 (Homo sapiens (Human))	BDBM50520945 (CHEMBL4584571) Show SMILES Cn1cccc1-c1ccc(-c2ccc(-c3ccc(-c4ccccc4)n3C)n2C)n1C Show InChI InChI=1S/C26H26N4/c1-27-18-8-11-21(27)22-14-15-25(29(22)3)26-17-16-24(30(26)4)23-13-12-20(28(23)2)19-9-6-5-7-10-19/h5-18H,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.12E+4	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of wild type His-tagged PCSK9 (unknown origin) binding to recombinant LDLR-AB domain (unknown origin) after 2 hrs by fluorescence assay				Eur J Med Chem 162: 212-233 (2019) Article DOI: 10.1016/j.ejmech.2018.11.011
					More data for this Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (Homo sapiens (Human))	BDBM50520945 (CHEMBL4584571) Show SMILES Cn1cccc1-c1ccc(-c2ccc(-c3ccc(-c4ccccc4)n3C)n2C)n1C Show InChI InChI=1S/C26H26N4/c1-27-18-8-11-21(27)22-14-15-25(29(22)3)26-17-16-24(30(26)4)23-13-12-20(28(23)2)19-9-6-5-7-10-19/h5-18H,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6.04E+3	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of PCSK9 in human HepG2 cells assessed as increase in LDL uptake after 24 hrs by fluorescence assay				Eur J Med Chem 162: 212-233 (2019) Article DOI: 10.1016/j.ejmech.2018.11.011
					More data for this Ligand-Target Pair