BDBM50521053 CHEMBL4578059

SMILES: COc1cc(cc(OC)c1OC)C(=O)Nc1c([nH]c2cc(Cl)ccc12)C(=O)c1ccc(Cl)cc1

InChI Key: InChIKey=IOHBTASVMGOVRU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50521053   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tubulin beta chain (Sus scrofa)	BDBM50521053 (CHEMBL4578059) Show SMILES COc1cc(cc(OC)c1OC)C(=O)Nc1c([nH]c2cc(Cl)ccc12)C(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C25H20Cl2N2O5/c1-32-19-10-14(11-20(33-2)24(19)34-3)25(31)29-21-17-9-8-16(27)12-18(17)28-22(21)23(30)13-4-6-15(26)7-5-13/h4-12,28H,1-3H3,(H,29,31)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Southern Medical University Curated by ChEMBL					Assay Description Inhibition of pig brain tubulin polymerization by spectrophotometric analysis				Eur J Med Chem 162: 525-533 (2019) Article DOI: 10.1016/j.ejmech.2018.11.038
					More data for this Ligand-Target Pair