BDBM50521617 CHEMBL4469049

SMILES: CCOC(=O)c1[nH]c2cc(Cl)ccc2c1\C=C\C(=O)NCc1ccccc1Cl

InChI Key: InChIKey=UMBPNPYHHWQWBF-MDZDMXLPSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50521617   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 15-lipoxygenase (Homo sapiens (Human))	BDBM50521617 (CHEMBL4469049) Show SMILES CCOC(=O)c1[nH]c2cc(Cl)ccc2c1\C=C\C(=O)NCc1ccccc1Cl Show InChI InChI=1S/C21H18Cl2N2O3/c1-2-28-21(27)20-16(15-8-7-14(22)11-18(15)25-20)9-10-19(26)24-12-13-5-3-4-6-17(13)23/h3-11,25H,2,12H2,1H3,(H,24,26)/b10-9+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	740	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human recombinant N-terminal His6-tagged 15-LOX1 expressed in Escherichia coli BL21(DE3) using linoleic acid as substrate preincubated ...				J Med Chem 62: 4624-4637 (2019) Article DOI: 10.1021/acs.jmedchem.9b00212
					More data for this Ligand-Target Pair