BDBM50522309 CHEMBL4532536

SMILES: Cc1ccc(cc1)S(=O)(=O)N1C(=O)NC2(CCCc3ccccc23)C1=O

InChI Key: InChIKey=LXXQXOMQCGHKBG-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50522309   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aldose reductase (Rattus norvegicus)	BDBM50522309 (CHEMBL4532536) Show SMILES Cc1ccc(cc1)S(=O)(=O)N1C(=O)NC2(CCCc3ccccc23)C1=O Show InChI InChI=1S/C19H18N2O4S/c1-13-8-10-15(11-9-13)26(24,25)21-17(22)19(20-18(21)23)12-4-6-14-5-2-3-7-16(14)19/h2-3,5,7-11H,4,6,12H2,1H3,(H,20,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.56E+3	n/a	n/a	n/a	n/a	n/a	n/a
Quaid-i-Azam University Curated by ChEMBL					Assay Description Inhibition of ALR2 in rat lens assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chromatographic...				Eur J Med Chem 168: 154-175 (2019) Article DOI: 10.1016/j.ejmech.2019.02.036
					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50522309 (CHEMBL4532536) Show SMILES Cc1ccc(cc1)S(=O)(=O)N1C(=O)NC2(CCCc3ccccc23)C1=O Show InChI InChI=1S/C19H18N2O4S/c1-13-8-10-15(11-9-13)26(24,25)21-17(22)19(20-18(21)23)12-4-6-14-5-2-3-7-16(14)19/h2-3,5,7-11H,4,6,12H2,1H3,(H,20,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Quaid-i-Azam University Curated by ChEMBL					Assay Description Inhibition of ALR2 in rat erythrocytes assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chromat...				Eur J Med Chem 168: 154-175 (2019) Article DOI: 10.1016/j.ejmech.2019.02.036
					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50522309 (CHEMBL4532536) Show SMILES Cc1ccc(cc1)S(=O)(=O)N1C(=O)NC2(CCCc3ccccc23)C1=O Show InChI InChI=1S/C19H18N2O4S/c1-13-8-10-15(11-9-13)26(24,25)21-17(22)19(20-18(21)23)12-4-6-14-5-2-3-7-16(14)19/h2-3,5,7-11H,4,6,12H2,1H3,(H,20,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.72E+3	n/a	n/a	n/a	n/a	n/a	n/a
Quaid-i-Azam University Curated by ChEMBL					Assay Description Inhibition of ALR2 in rat sciatic nerve assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chroma...				Eur J Med Chem 168: 154-175 (2019) Article DOI: 10.1016/j.ejmech.2019.02.036
					More data for this Ligand-Target Pair
Aldose reductase (Homo sapiens (Human))	BDBM50522309 (CHEMBL4532536) Show SMILES Cc1ccc(cc1)S(=O)(=O)N1C(=O)NC2(CCCc3ccccc23)C1=O Show InChI InChI=1S/C19H18N2O4S/c1-13-8-10-15(11-9-13)26(24,25)21-17(22)19(20-18(21)23)12-4-6-14-5-2-3-7-16(14)19/h2-3,5,7-11H,4,6,12H2,1H3,(H,20,23)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Quaid-i-Azam University Curated by ChEMBL					Assay Description Inhibition of human recombinant ALR2 expressed in Escherichia coli using DL-glyceraldehyde as substrate and NADPH preincubated for 5 mins followed by...				Eur J Med Chem 168: 154-175 (2019) Article DOI: 10.1016/j.ejmech.2019.02.036
					More data for this Ligand-Target Pair