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BDBM50522734 CHEMBL4444819

SMILES: CC(C)CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1cc2c(C)c(ccc2n1)-c1ccc(cc1Cl)C(F)(F)F

InChI Key: InChIKey=BXTRFSPRTKFWOI-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50522734   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucagon receptor


(Homo sapiens (Human))		BDBM50522734
PNG
(CHEMBL4444819)
Show SMILES CC(C)CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1cc2c(C)c(ccc2n1)-c1ccc(cc1Cl)C(F)(F)F
Show InChI InChI=1S/C30H29ClF3N3O3/c1-17(2)14-27(19-4-6-20(7-5-19)29(40)35-13-12-28(38)39)37-16-24-18(3)22(10-11-26(24)36-37)23-9-8-21(15-25(23)31)30(32,33)34/h4-11,15-17,27H,12-14H2,1-3H3,(H,35,40)(H,38,39)
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PC cid
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Article
PubMed
 29n/an/an/an/an/an/an/an/a



Janssen Research & Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at full length human recombinant GCGR transfected in HEK293 cells assessed as inhibition of glucagon-stimulated cAMP by by LANCE ...

Bioorg Med Chem Lett 29: 1974-1980 (2019)


Article DOI: 10.1016/j.bmcl.2019.05.036
More data for this
Ligand-Target Pair