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BDBM50522737 CHEMBL4469925

SMILES: COc1c(ccc2nn(cc12)C(CC(C)C)c1ccc(cc1)C(=O)NCCC(O)=O)-c1ccc(cc1Cl)C(F)(F)F

InChI Key: InChIKey=CKMPOAFHGMTZND-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50522737   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucagon receptor


(Homo sapiens (Human))		BDBM50522737
PNG
(CHEMBL4469925)
Show SMILES COc1c(ccc2nn(cc12)C(CC(C)C)c1ccc(cc1)C(=O)NCCC(O)=O)-c1ccc(cc1Cl)C(F)(F)F
Show InChI InChI=1S/C30H29ClF3N3O4/c1-17(2)14-26(18-4-6-19(7-5-18)29(40)35-13-12-27(38)39)37-16-23-25(36-37)11-10-22(28(23)41-3)21-9-8-20(15-24(21)31)30(32,33)34/h4-11,15-17,26H,12-14H2,1-3H3,(H,35,40)(H,38,39)
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Article
PubMed
 22n/an/an/an/an/an/an/an/a



Janssen Research & Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at full length human recombinant GCGR transfected in HEK293 cells assessed as inhibition of glucagon-stimulated cAMP by by LANCE ...

Bioorg Med Chem Lett 29: 1974-1980 (2019)


Article DOI: 10.1016/j.bmcl.2019.05.036
More data for this
Ligand-Target Pair