BDBM50523478 CHEMBL4473792

SMILES: Cc1ccc(cc1)C1CCN(CC(=O)Nc2cccc(C)c2)CC1

InChI Key: InChIKey=AXJOWWAHGHUVEF-UHFFFAOYSA-N

Data: 3 KI  4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50523478   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50523478 (CHEMBL4473792) Show SMILES Cc1ccc(cc1)C1CCN(CC(=O)Nc2cccc(C)c2)CC1 Show InChI InChI=1S/C21H26N2O/c1-16-6-8-18(9-7-16)19-10-12-23(13-11-19)15-21(24)22-20-5-3-4-17(2)14-20/h3-9,14,19H,10-13,15H2,1-2H3,(H,22,24)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rowan University Curated by ChEMBL					Assay Description Displacement of [3H]N-methylspiperone from human D4.4 receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting me...				J Med Chem 62: 3722-3740 (2019) Article DOI: 10.1021/acs.jmedchem.9b00231
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50523478 (CHEMBL4473792) Show SMILES Cc1ccc(cc1)C1CCN(CC(=O)Nc2cccc(C)c2)CC1 Show InChI InChI=1S/C21H26N2O/c1-16-6-8-18(9-7-16)19-10-12-23(13-11-19)15-21(24)22-20-5-3-4-17(2)14-20/h3-9,14,19H,10-13,15H2,1-2H3,(H,22,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3.68E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rowan University Curated by ChEMBL					Assay Description Displacement of [3H]N-methylspiperone from human D3 receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting meth...				J Med Chem 62: 3722-3740 (2019) Article DOI: 10.1021/acs.jmedchem.9b00231
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50523478 (CHEMBL4473792) Show SMILES Cc1ccc(cc1)C1CCN(CC(=O)Nc2cccc(C)c2)CC1 Show InChI InChI=1S/C21H26N2O/c1-16-6-8-18(9-7-16)19-10-12-23(13-11-19)15-21(24)22-20-5-3-4-17(2)14-20/h3-9,14,19H,10-13,15H2,1-2H3,(H,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	7.82E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rowan University Curated by ChEMBL					Assay Description Displacement of [3H]N-methylspiperone from human D2L receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting met...				J Med Chem 62: 3722-3740 (2019) Article DOI: 10.1021/acs.jmedchem.9b00231
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50523478 (CHEMBL4473792) Show SMILES Cc1ccc(cc1)C1CCN(CC(=O)Nc2cccc(C)c2)CC1 Show InChI InChI=1S/C21H26N2O/c1-16-6-8-18(9-7-16)19-10-12-23(13-11-19)15-21(24)22-20-5-3-4-17(2)14-20/h3-9,14,19H,10-13,15H2,1-2H3,(H,22,24)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rowan University Curated by ChEMBL					Assay Description Antagonist activity at human D4 receptor expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta-arrestin recruitment measured after...				J Med Chem 62: 3722-3740 (2019) Article DOI: 10.1021/acs.jmedchem.9b00231
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50523478 (CHEMBL4473792) Show SMILES Cc1ccc(cc1)C1CCN(CC(=O)Nc2cccc(C)c2)CC1 Show InChI InChI=1S/C21H26N2O/c1-16-6-8-18(9-7-16)19-10-12-23(13-11-19)15-21(24)22-20-5-3-4-17(2)14-20/h3-9,14,19H,10-13,15H2,1-2H3,(H,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.92E+4	n/a	n/a	n/a	n/a	n/a	n/a
Rowan University Curated by ChEMBL					Assay Description Antagonist activity at human D2L receptor expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta-arrestin recruitment measured afte...				J Med Chem 62: 3722-3740 (2019) Article DOI: 10.1021/acs.jmedchem.9b00231
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50523478 (CHEMBL4473792) Show SMILES Cc1ccc(cc1)C1CCN(CC(=O)Nc2cccc(C)c2)CC1 Show InChI InChI=1S/C21H26N2O/c1-16-6-8-18(9-7-16)19-10-12-23(13-11-19)15-21(24)22-20-5-3-4-17(2)14-20/h3-9,14,19H,10-13,15H2,1-2H3,(H,22,24)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rowan University Curated by ChEMBL					Assay Description Antagonist activity at human D4 receptor expressed in CHOK1 cells assessed as suppression of dopamine-induced inhibition of forskolin-stimulated cAMP...				J Med Chem 62: 3722-3740 (2019) Article DOI: 10.1021/acs.jmedchem.9b00231
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50523478 (CHEMBL4473792) Show SMILES Cc1ccc(cc1)C1CCN(CC(=O)Nc2cccc(C)c2)CC1 Show InChI InChI=1S/C21H26N2O/c1-16-6-8-18(9-7-16)19-10-12-23(13-11-19)15-21(24)22-20-5-3-4-17(2)14-20/h3-9,14,19H,10-13,15H2,1-2H3,(H,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.48E+4	n/a	n/a	n/a	n/a	n/a	n/a
Rowan University Curated by ChEMBL					Assay Description Antagonist activity at human D2L receptor expressed in CHOK1 cells assessed as suppression of dopamine-induced inhibition of forskolin-stimulated cAM...				J Med Chem 62: 3722-3740 (2019) Article DOI: 10.1021/acs.jmedchem.9b00231
					More data for this Ligand-Target Pair