BDBM50523629 CHEMBL4564327

SMILES: Cc1cnc2cc(CC[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(N)ncnc34)c(Cl)cn12

InChI Key: InChIKey=IXQKPZSMAFSERF-QVSURHGTSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50523629   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50523629 (CHEMBL4564327) Show SMILES Cc1cnc2cc(CC[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(N)ncnc34)c(Cl)cn12 |r| Show InChI InChI=1S/C21H23ClN6O2/c1-11-8-24-17-7-12(15(22)9-28(11)17)2-3-13-6-16(19(30)18(13)29)27-5-4-14-20(23)25-10-26-21(14)27/h4-5,7-10,13,16,18-19,29-30H,2-3,6H2,1H3,(H2,23,25,26)/t13-,16+,18+,19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Prelude Therapeutics Curated by ChEMBL					Assay Description Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...				Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042
					More data for this Ligand-Target Pair
PRMT5/MEP50 Enzyme (Homo sapiens (Human))	BDBM50523629 (CHEMBL4564327) Show SMILES Cc1cnc2cc(CC[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(N)ncnc34)c(Cl)cn12 |r| Show InChI InChI=1S/C21H23ClN6O2/c1-11-8-24-17-7-12(15(22)9-28(11)17)2-3-13-6-16(19(30)18(13)29)27-5-4-14-20(23)25-10-26-21(14)27/h4-5,7-10,13,16,18-19,29-30H,2-3,6H2,1H3,(H2,23,25,26)/t13-,16+,18+,19-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Prelude Therapeutics Curated by ChEMBL					Assay Description Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...				Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042
					More data for this Ligand-Target Pair