BDBM50523632 CHEMBL4454122

SMILES: Cl.Nc1ncnc2n(ccc12)[C@@H]1O[C@H](CN2CC(F)(F)CC22CCNCC2)[C@@H](O)[C@H]1O

InChI Key: InChIKey=OOYJVUIGFXMRTL-SZTAYTFXSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50523632   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50523632 (CHEMBL4454122) Show SMILES Cl.Nc1ncnc2n(ccc12)[C@@H]1O[C@H](CN2CC(F)(F)CC22CCNCC2)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C19H26F2N6O3.ClH/c20-19(21)8-18(2-4-23-5-3-18)26(9-19)7-12-13(28)14(29)17(30-12)27-6-1-11-15(22)24-10-25-16(11)27;/h1,6,10,12-14,17,23,28-29H,2-5,7-9H2,(H2,22,24,25);1H/t12-,13-,14-,17-;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.70	n/a	n/a	n/a	n/a	n/a	n/a
Prelude Therapeutics Curated by ChEMBL					Assay Description Inhibition of PRMT5 (unknown origin) assessed as reduction in SAH formation using histone H2A and SAM incubated for 60 mins by high throughput mass s...				Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50523632 (CHEMBL4454122) Show SMILES Cl.Nc1ncnc2n(ccc12)[C@@H]1O[C@H](CN2CC(F)(F)CC22CCNCC2)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C19H26F2N6O3.ClH/c20-19(21)8-18(2-4-23-5-3-18)26(9-19)7-12-13(28)14(29)17(30-12)27-6-1-11-15(22)24-10-25-16(11)27;/h1,6,10,12-14,17,23,28-29H,2-5,7-9H2,(H2,22,24,25);1H/t12-,13-,14-,17-;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Prelude Therapeutics Curated by ChEMBL					Assay Description Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production incubated for 48 hrs by immunohistochemistry analysis				Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042
					More data for this Ligand-Target Pair