BDBM50523662 CHEMBL4465375

SMILES: [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cc(C#C)c2c(N)ncnc12)[C@H](O)c1ccc(Cl)cc1

InChI Key: InChIKey=NJWHFGKLLBVQAN-PPLBCVRQSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50523662   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PRMT5/MEP50 Enzyme (Homo sapiens (Human))	BDBM50523662 (CHEMBL4465375) Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cc(C#C)c2c(N)ncnc12)[C@H](O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C19H17ClN4O4/c1-2-9-7-24(18-12(9)17(21)22-8-23-18)19-15(27)14(26)16(28-19)13(25)10-3-5-11(20)6-4-10/h1,3-8,13-16,19,25-27H,(H2,21,22,23)/t13-,14+,15-,16-,19-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Prelude Therapeutics Curated by ChEMBL					Assay Description Inhibition of PRMT5 (unknown origin)/MEP50 (unknown origin) using histone H2 as substrate preincubated for 15 to 20 mins followed by S-[methyl-3H]ade...				Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042
					More data for this Ligand-Target Pair