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BDBM50523827 CHEMBL4516094

SMILES: COc1cc(\C=C2/C(=O)Nc3ccc(Nc4ccco4)cc23)cc(OC)c1OC

InChI Key: InChIKey=BHPDHKMJRCEADL-SXGWCWSVSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50523827   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM50523827
PNG
(CHEMBL4516094)
Show SMILES COc1cc(\C=C2/C(=O)Nc3ccc(Nc4ccco4)cc23)cc(OC)c1OC
Show InChI InChI=1S/C22H20N2O5/c1-26-18-10-13(11-19(27-2)21(18)28-3)9-16-15-12-14(23-20-5-4-8-29-20)6-7-17(15)24-22(16)25/h4-12,23H,1-3H3,(H,24,25)/b16-9-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

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antibodypedia
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GSK3beta using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate measured after 60 mins by ADP-Glo luminescence assay

Bioorg Med Chem 27: 1804-1817 (2019)


Article DOI: 10.1016/j.bmc.2019.03.028
More data for this
Ligand-Target Pair