BDBM50524281 CHEMBL4440586

SMILES: COc1cc2ncc(C#N)c(Nc3cccc(c3)C#C)c2cc1OC

InChI Key: InChIKey=ILBOKEFXMPHJKP-UHFFFAOYSA-N

Data: 2 IC50  2 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50524281   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50524281 (CHEMBL4440586) Show SMILES COc1cc2ncc(C#N)c(Nc3cccc(c3)C#C)c2cc1OC Show InChI InChI=1S/C20H15N3O2/c1-4-13-6-5-7-15(8-13)23-20-14(11-21)12-22-17-10-19(25-3)18(24-2)9-16(17)20/h1,5-10,12H,2-3H3,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Binding affinity to wild-type human partial length EGFR (R669 to V1011 residues) expressed in bacterial expression system by Kinomescan method				J Med Chem 62: 4772-4778 (2019) Article DOI: 10.1021/acs.jmedchem.9b00350
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase GAK (Homo sapiens (Human))	BDBM50524281 (CHEMBL4440586) Show SMILES COc1cc2ncc(C#N)c(Nc3cccc(c3)C#C)c2cc1OC Show InChI InChI=1S/C20H15N3O2/c1-4-13-6-5-7-15(8-13)23-20-14(11-21)12-22-17-10-19(25-3)18(24-2)9-16(17)20/h1,5-10,12H,2-3H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assay				J Med Chem 62: 4772-4778 (2019) Article DOI: 10.1021/acs.jmedchem.9b00350
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50524281 (CHEMBL4440586) Show SMILES COc1cc2ncc(C#N)c(Nc3cccc(c3)C#C)c2cc1OC Show InChI InChI=1S/C20H15N3O2/c1-4-13-6-5-7-15(8-13)23-20-14(11-21)12-22-17-10-19(25-3)18(24-2)9-16(17)20/h1,5-10,12H,2-3H3,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...				J Med Chem 62: 4772-4778 (2019) Article DOI: 10.1021/acs.jmedchem.9b00350
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase GAK (Homo sapiens (Human))	BDBM50524281 (CHEMBL4440586) Show SMILES COc1cc2ncc(C#N)c(Nc3cccc(c3)C#C)c2cc1OC Show InChI InChI=1S/C20H15N3O2/c1-4-13-6-5-7-15(8-13)23-20-14(11-21)12-22-17-10-19(25-3)18(24-2)9-16(17)20/h1,5-10,12H,2-3H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan method				J Med Chem 62: 4772-4778 (2019) Article DOI: 10.1021/acs.jmedchem.9b00350
					More data for this Ligand-Target Pair