BDBM50525386 CHEMBL4451333

SMILES: COc1ccc(cc1)-c1nnc(Nc2cccc(Cl)c2)c2ccccc12

InChI Key: InChIKey=ZCQMIKJVVOBTAZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50525386   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 5A (Bos taurus)	BDBM50525386 (CHEMBL4451333) Show SMILES COc1ccc(cc1)-c1nnc(Nc2cccc(Cl)c2)c2ccccc12 Show InChI InChI=1S/C21H16ClN3O/c1-26-17-11-9-14(10-12-17)20-18-7-2-3-8-19(18)21(25-24-20)23-16-6-4-5-15(22)13-16/h2-13H,1H3,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Strasbourg Curated by ChEMBL					Assay Description Inhibition of bovine aortic smooth muscle PDE5 using cGMP as substrate incubated for 30 mins in presence of EGTA and [3H]cGMP by liquid scintillation...				Eur J Med Chem 177: 269-290 (2019) Article DOI: 10.1016/j.ejmech.2019.05.026
					More data for this Ligand-Target Pair