BDBM50525400 CHEMBL4566048

SMILES: COc1ccc(CNc2nnc(Cl)c3ccc(cc23)C(F)(F)F)cc1

InChI Key: InChIKey=MPINHSCEKVSVTB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50525400   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 5A (Bos taurus)	BDBM50525400 (CHEMBL4566048) Show SMILES COc1ccc(CNc2nnc(Cl)c3ccc(cc23)C(F)(F)F)cc1 Show InChI InChI=1S/C17H13ClF3N3O/c1-25-12-5-2-10(3-6-12)9-22-16-14-8-11(17(19,20)21)4-7-13(14)15(18)23-24-16/h2-8H,9H2,1H3,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Strasbourg Curated by ChEMBL					Assay Description Inhibition of bovine aortic smooth muscle PDE5 using cGMP as substrate incubated for 30 mins in presence of EGTA and [3H]cGMP by liquid scintillation...				Eur J Med Chem 177: 269-290 (2019) Article DOI: 10.1016/j.ejmech.2019.05.026
					More data for this Ligand-Target Pair