BDBM50527237 CHEMBL4464974

SMILES: Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)c(F)c(c1)-c1ccccn1

InChI Key: InChIKey=YZLKUOYGMDRYOD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50527237   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone acetyltransferase KAT6A (Homo sapiens)	BDBM50527237 (CHEMBL4464974) Show SMILES Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)c(F)c(c1)-c1ccccn1 Show InChI InChI=1S/C19H15F2N3O3S/c1-12-10-13(16-7-4-5-9-22-16)18(21)14(11-12)19(25)23-24-28(26,27)17-8-3-2-6-15(17)20/h2-11,24H,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Monash University (Parkville Campus) Curated by ChEMBL					Assay Description Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...				J Med Chem 63: 4655-4684 (2020) Article DOI: 10.1021/acs.jmedchem.9b02071
					More data for this Ligand-Target Pair