null

SMILES: CCCOc1cc(F)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F

InChI Key: InChIKey=HZQDBKLKPICXSR-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50527334   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone acetyltransferase KAT6A (Homo sapiens)	BDBM50527334 (CHEMBL4453580 | US10829446, Compound 111) Show SMILES CCCOc1cc(F)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F Show InChI InChI=1S/C16H16F2N2O4S/c1-2-7-24-13-9-11(8-12(17)10-13)16(21)19-20-25(22,23)15-6-4-3-5-14(15)18/h3-6,8-10,20H,2,7H2,1H3,(H,19,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
MONASH UNIVERSITY; The Walter and Eliza Hall Institute of Medical Research US Patent					Assay Description Active Moz protein was expressed as N-terminal fusion protein with a His6 tag in BL21 E. coli cells. Protein purification was performed via nickel-im...				US Patent US10829446 (2020)
					More data for this Ligand-Target Pair
Histone acetyltransferase KAT6A (Homo sapiens)	BDBM50527334 (CHEMBL4453580 | US10829446, Compound 111) Show SMILES CCCOc1cc(F)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F Show InChI InChI=1S/C16H16F2N2O4S/c1-2-7-24-13-9-11(8-12(17)10-13)16(21)19-20-25(22,23)15-6-4-3-5-14(15)18/h3-6,8-10,20H,2,7H2,1H3,(H,19,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
Monash University (Parkville Campus) Curated by ChEMBL					Assay Description Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...				J Med Chem 63: 4655-4684 (2020) Article DOI: 10.1021/acs.jmedchem.9b02071
					More data for this Ligand-Target Pair