BDBM50527355 CHEMBL4456585::US10829446, Compound 46
SMILES: Fc1cc(cc(c1)-c1ccccn1)C(=O)NNS(=O)(=O)c1ccccc1F
InChI Key: InChIKey=QLXULUNLCRKWRD-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone acetyltransferase KAT6A (Homo sapiens) | BDBM50527355 (CHEMBL4456585 | US10829446, Compound 46) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | US Patent | n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
MONASH UNIVERSITY; The Walter and Eliza Hall Institute of Medical Research US Patent | Assay Description Active Moz protein was expressed as N-terminal fusion protein with a His6 tag in BL21 E. coli cells. Protein purification was performed via nickel-im... | US Patent US10829446 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone acetyltransferase KAT6A (Homo sapiens) | BDBM50527355 (CHEMBL4456585 | US10829446, Compound 46) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus) Curated by ChEMBL | Assay Description Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ... | J Med Chem 63: 4655-4684 (2020) Article DOI: 10.1021/acs.jmedchem.9b02071 | |||||||||||
More data for this Ligand-Target Pair |