BDBM50527634 CHEMBL4456827

SMILES: CC[C@H](Nc1ncnc(N)c1Cl)c1nc2cccc(NCc3ccc(cn3)C(=O)NO)c2c(=O)n1-c1ccccc1

InChI Key: InChIKey=CFBUBQDTEDCOTD-IBGZPJMESA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50527634   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50527634 (CHEMBL4456827) Show SMILES CC[C@H](Nc1ncnc(N)c1Cl)c1nc2cccc(NCc3ccc(cn3)C(=O)NO)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C28H26ClN9O3/c1-2-19(35-25-23(29)24(30)33-15-34-25)26-36-21-10-6-9-20(22(21)28(40)38(26)18-7-4-3-5-8-18)32-14-17-12-11-16(13-31-17)27(39)37-41/h3-13,15,19,32,41H,2,14H2,1H3,(H,37,39)(H3,30,33,34,35)/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	189	n/a	n/a	n/a	n/a	n/a	n/a
National Center for Advancing Translational Sciences Curated by ChEMBL					Assay Description Inhibition of human PI3Kdelta assessed as reduction in PIP3 product complex formation by measuring displacement of biotin-labelled PIP3 from complex ...				J Med Chem 63: 4256-4292 (2020) Article DOI: 10.1021/acs.jmedchem.0c00193
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50527634 (CHEMBL4456827) Show SMILES CC[C@H](Nc1ncnc(N)c1Cl)c1nc2cccc(NCc3ccc(cn3)C(=O)NO)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C28H26ClN9O3/c1-2-19(35-25-23(29)24(30)33-15-34-25)26-36-21-10-6-9-20(22(21)28(40)38(26)18-7-4-3-5-8-18)32-14-17-12-11-16(13-31-17)27(39)37-41/h3-13,15,19,32,41H,2,14H2,1H3,(H,37,39)(H3,30,33,34,35)/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
National Center for Advancing Translational Sciences Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged HDAC6 (1 to 1125 residues) expressed in baculovirus infected insect cells using fluorogenic pep...				J Med Chem 63: 4256-4292 (2020) Article DOI: 10.1021/acs.jmedchem.0c00193
					More data for this Ligand-Target Pair