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BDBM50528317 CHEMBL4564908

SMILES: ONC(=O)C(NC(=O)Cc1ccccc1)c1ccc(cc1)-c1cc(F)c(F)c(F)c1

InChI Key: InChIKey=FHHYXNVHBSDHNP-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50528317   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Aminopeptidase


(Homo sapiens (Human))		BDBM50528317
PNG
(CHEMBL4564908)
Show SMILES ONC(=O)C(NC(=O)Cc1ccccc1)c1ccc(cc1)-c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C22H17F3N2O3/c23-17-11-16(12-18(24)20(17)25)14-6-8-15(9-7-14)21(22(29)27-30)26-19(28)10-13-4-2-1-3-5-13/h1-9,11-12,21,30H,10H2,(H,26,28)(H,27,29)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 4.42E+3n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of soluble human APN ectodomain stably expressed in HEK293 GnTI(-) cells using H-Leu-NHMec as substrate preincubated for 10 mins followed ...

J Med Chem 62: 7185-7209 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00757
More data for this
Ligand-Target Pair