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BDBM50528322 CHEMBL4579696

SMILES: COc1ccc(cc1OC)C(=O)NC(C(=O)NO)c1ccc(cc1)-c1cc(F)c(F)c(F)c1

InChI Key: InChIKey=IORFNASODJLBSD-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50528322   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Aminopeptidase


(Homo sapiens (Human))		BDBM50528322
PNG
(CHEMBL4579696)
Show SMILES COc1ccc(cc1OC)C(=O)NC(C(=O)NO)c1ccc(cc1)-c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C23H19F3N2O5/c1-32-18-8-7-14(11-19(18)33-2)22(29)27-21(23(30)28-31)13-5-3-12(4-6-13)15-9-16(24)20(26)17(25)10-15/h3-11,21,31H,1-2H3,(H,27,29)(H,28,30)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

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antibodypedia
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PC cid
PC sid
UniChem
Article
PubMed
 175n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of soluble human APN ectodomain stably expressed in HEK293 GnTI(-) cells using H-Leu-NHMec as substrate preincubated for 10 mins followed ...

J Med Chem 62: 7185-7209 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00757
More data for this
Ligand-Target Pair