Found 9 hits for monomerid = 50528415 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50528415
(CHEMBL4457064)Show SMILES O[C@H]([C@@H](O)C(O)=O)C(O)=O.Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1 |r,wU:26.26,wD:1.0,2.2,31.33,(23.87,-52,;23.87,-53.52,;25.19,-54.29,;25.19,-55.81,;26.51,-53.52,;27.84,-54.29,;26.51,-52,;22.55,-54.29,;21.23,-53.52,;22.55,-55.81,;7.85,-50.48,;7.53,-51.98,;6.12,-52.61,;6.28,-54.14,;7.78,-54.46,;8.41,-55.87,;8.56,-53.13,;10.09,-52.98,;11.12,-54.12,;12.52,-53.5,;12.37,-51.97,;10.87,-51.64,;10.24,-50.24,;13.85,-54.28,;13.85,-55.82,;15.19,-53.51,;16.52,-54.28,;16.52,-55.82,;17.85,-56.59,;19.19,-55.83,;19.19,-54.28,;17.86,-53.51,;17.87,-51.98,;16.53,-51.21,;16.53,-49.66,;17.86,-48.89,;17.86,-47.35,;19.2,-49.66,;20.53,-48.88,;19.2,-51.21,)| Show InChI InChI=1S/C20H18Cl2F2N4O2.C4H6O6/c1-28-18(13(21)8-26-28)12-7-17(30-19(12)22)20(29)27-16-9-25-5-4-11(16)10-2-3-14(23)15(24)6-10;5-1(3(7)8)2(6)4(9)10/h2-3,6-8,11,16,25H,4-5,9H2,1H3,(H,27,29);1-2,5-6H,(H,7,8)(H,9,10)/t11-,16+;1-,2-/m01/s1 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human Akt1 expressed in Escherichia coli using STK Substrate 2-biotin as substrate incubated for 1 hr by HTRF assay |
J Med Chem 62: 7264-7288 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00891 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha 1
(Homo sapiens (Human)) | BDBM50528415
(CHEMBL4457064)Show SMILES O[C@H]([C@@H](O)C(O)=O)C(O)=O.Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1 |r,wU:26.26,wD:1.0,2.2,31.33,(23.87,-52,;23.87,-53.52,;25.19,-54.29,;25.19,-55.81,;26.51,-53.52,;27.84,-54.29,;26.51,-52,;22.55,-54.29,;21.23,-53.52,;22.55,-55.81,;7.85,-50.48,;7.53,-51.98,;6.12,-52.61,;6.28,-54.14,;7.78,-54.46,;8.41,-55.87,;8.56,-53.13,;10.09,-52.98,;11.12,-54.12,;12.52,-53.5,;12.37,-51.97,;10.87,-51.64,;10.24,-50.24,;13.85,-54.28,;13.85,-55.82,;15.19,-53.51,;16.52,-54.28,;16.52,-55.82,;17.85,-56.59,;19.19,-55.83,;19.19,-54.28,;17.86,-53.51,;17.87,-51.98,;16.53,-51.21,;16.53,-49.66,;17.86,-48.89,;17.86,-47.35,;19.2,-49.66,;20.53,-48.88,;19.2,-51.21,)| Show InChI InChI=1S/C20H18Cl2F2N4O2.C4H6O6/c1-28-18(13(21)8-26-28)12-7-17(30-19(12)22)20(29)27-16-9-25-5-4-11(16)10-2-3-14(23)15(24)6-10;5-1(3(7)8)2(6)4(9)10/h2-3,6-8,11,16,25H,4-5,9H2,1H3,(H,27,29);1-2,5-6H,(H,7,8)(H,9,10)/t11-,16+;1-,2-/m01/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of RSK1 (unknown origin) by mobility shift assay |
J Med Chem 62: 7264-7288 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00891 |
More data for this Ligand-Target Pair | |
Protein kinase C (PKC)
(Homo sapiens (Human)) | BDBM50528415
(CHEMBL4457064)Show SMILES O[C@H]([C@@H](O)C(O)=O)C(O)=O.Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1 |r,wU:26.26,wD:1.0,2.2,31.33,(23.87,-52,;23.87,-53.52,;25.19,-54.29,;25.19,-55.81,;26.51,-53.52,;27.84,-54.29,;26.51,-52,;22.55,-54.29,;21.23,-53.52,;22.55,-55.81,;7.85,-50.48,;7.53,-51.98,;6.12,-52.61,;6.28,-54.14,;7.78,-54.46,;8.41,-55.87,;8.56,-53.13,;10.09,-52.98,;11.12,-54.12,;12.52,-53.5,;12.37,-51.97,;10.87,-51.64,;10.24,-50.24,;13.85,-54.28,;13.85,-55.82,;15.19,-53.51,;16.52,-54.28,;16.52,-55.82,;17.85,-56.59,;19.19,-55.83,;19.19,-54.28,;17.86,-53.51,;17.87,-51.98,;16.53,-51.21,;16.53,-49.66,;17.86,-48.89,;17.86,-47.35,;19.2,-49.66,;20.53,-48.88,;19.2,-51.21,)| Show InChI InChI=1S/C20H18Cl2F2N4O2.C4H6O6/c1-28-18(13(21)8-26-28)12-7-17(30-19(12)22)20(29)27-16-9-25-5-4-11(16)10-2-3-14(23)15(24)6-10;5-1(3(7)8)2(6)4(9)10/h2-3,6-8,11,16,25H,4-5,9H2,1H3,(H,27,29);1-2,5-6H,(H,7,8)(H,9,10)/t11-,16+;1-,2-/m01/s1 | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 156 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of PKC (unknown origin) |
J Med Chem 62: 7264-7288 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00891 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase AKT2
(Homo sapiens (Human)) | BDBM50528415
(CHEMBL4457064)Show SMILES O[C@H]([C@@H](O)C(O)=O)C(O)=O.Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1 |r,wU:26.26,wD:1.0,2.2,31.33,(23.87,-52,;23.87,-53.52,;25.19,-54.29,;25.19,-55.81,;26.51,-53.52,;27.84,-54.29,;26.51,-52,;22.55,-54.29,;21.23,-53.52,;22.55,-55.81,;7.85,-50.48,;7.53,-51.98,;6.12,-52.61,;6.28,-54.14,;7.78,-54.46,;8.41,-55.87,;8.56,-53.13,;10.09,-52.98,;11.12,-54.12,;12.52,-53.5,;12.37,-51.97,;10.87,-51.64,;10.24,-50.24,;13.85,-54.28,;13.85,-55.82,;15.19,-53.51,;16.52,-54.28,;16.52,-55.82,;17.85,-56.59,;19.19,-55.83,;19.19,-54.28,;17.86,-53.51,;17.87,-51.98,;16.53,-51.21,;16.53,-49.66,;17.86,-48.89,;17.86,-47.35,;19.2,-49.66,;20.53,-48.88,;19.2,-51.21,)| Show InChI InChI=1S/C20H18Cl2F2N4O2.C4H6O6/c1-28-18(13(21)8-26-28)12-7-17(30-19(12)22)20(29)27-16-9-25-5-4-11(16)10-2-3-14(23)15(24)6-10;5-1(3(7)8)2(6)4(9)10/h2-3,6-8,11,16,25H,4-5,9H2,1H3,(H,27,29);1-2,5-6H,(H,7,8)(H,9,10)/t11-,16+;1-,2-/m01/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <0.640 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human Akt2 by mobile shift assay |
J Med Chem 62: 7264-7288 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00891 |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50528415
(CHEMBL4457064)Show SMILES O[C@H]([C@@H](O)C(O)=O)C(O)=O.Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1 |r,wU:26.26,wD:1.0,2.2,31.33,(23.87,-52,;23.87,-53.52,;25.19,-54.29,;25.19,-55.81,;26.51,-53.52,;27.84,-54.29,;26.51,-52,;22.55,-54.29,;21.23,-53.52,;22.55,-55.81,;7.85,-50.48,;7.53,-51.98,;6.12,-52.61,;6.28,-54.14,;7.78,-54.46,;8.41,-55.87,;8.56,-53.13,;10.09,-52.98,;11.12,-54.12,;12.52,-53.5,;12.37,-51.97,;10.87,-51.64,;10.24,-50.24,;13.85,-54.28,;13.85,-55.82,;15.19,-53.51,;16.52,-54.28,;16.52,-55.82,;17.85,-56.59,;19.19,-55.83,;19.19,-54.28,;17.86,-53.51,;17.87,-51.98,;16.53,-51.21,;16.53,-49.66,;17.86,-48.89,;17.86,-47.35,;19.2,-49.66,;20.53,-48.88,;19.2,-51.21,)| Show InChI InChI=1S/C20H18Cl2F2N4O2.C4H6O6/c1-28-18(13(21)8-26-28)12-7-17(30-19(12)22)20(29)27-16-9-25-5-4-11(16)10-2-3-14(23)15(24)6-10;5-1(3(7)8)2(6)4(9)10/h2-3,6-8,11,16,25H,4-5,9H2,1H3,(H,27,29);1-2,5-6H,(H,7,8)(H,9,10)/t11-,16+;1-,2-/m01/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human ROCK1 by mobile shift assay |
J Med Chem 62: 7264-7288 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00891 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase AKT
(Homo sapiens (Human)) | BDBM50528415
(CHEMBL4457064)Show SMILES O[C@H]([C@@H](O)C(O)=O)C(O)=O.Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1 |r,wU:26.26,wD:1.0,2.2,31.33,(23.87,-52,;23.87,-53.52,;25.19,-54.29,;25.19,-55.81,;26.51,-53.52,;27.84,-54.29,;26.51,-52,;22.55,-54.29,;21.23,-53.52,;22.55,-55.81,;7.85,-50.48,;7.53,-51.98,;6.12,-52.61,;6.28,-54.14,;7.78,-54.46,;8.41,-55.87,;8.56,-53.13,;10.09,-52.98,;11.12,-54.12,;12.52,-53.5,;12.37,-51.97,;10.87,-51.64,;10.24,-50.24,;13.85,-54.28,;13.85,-55.82,;15.19,-53.51,;16.52,-54.28,;16.52,-55.82,;17.85,-56.59,;19.19,-55.83,;19.19,-54.28,;17.86,-53.51,;17.87,-51.98,;16.53,-51.21,;16.53,-49.66,;17.86,-48.89,;17.86,-47.35,;19.2,-49.66,;20.53,-48.88,;19.2,-51.21,)| Show InChI InChI=1S/C20H18Cl2F2N4O2.C4H6O6/c1-28-18(13(21)8-26-28)12-7-17(30-19(12)22)20(29)27-16-9-25-5-4-11(16)10-2-3-14(23)15(24)6-10;5-1(3(7)8)2(6)4(9)10/h2-3,6-8,11,16,25H,4-5,9H2,1H3,(H,27,29);1-2,5-6H,(H,7,8)(H,9,10)/t11-,16+;1-,2-/m01/s1 | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of Akt in human LNCaP cells assessed as reduction in PRAS40 phosphorylation at T246 residue after 1 hr by ELISA |
J Med Chem 62: 7264-7288 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00891 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50528415
(CHEMBL4457064)Show SMILES O[C@H]([C@@H](O)C(O)=O)C(O)=O.Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1 |r,wU:26.26,wD:1.0,2.2,31.33,(23.87,-52,;23.87,-53.52,;25.19,-54.29,;25.19,-55.81,;26.51,-53.52,;27.84,-54.29,;26.51,-52,;22.55,-54.29,;21.23,-53.52,;22.55,-55.81,;7.85,-50.48,;7.53,-51.98,;6.12,-52.61,;6.28,-54.14,;7.78,-54.46,;8.41,-55.87,;8.56,-53.13,;10.09,-52.98,;11.12,-54.12,;12.52,-53.5,;12.37,-51.97,;10.87,-51.64,;10.24,-50.24,;13.85,-54.28,;13.85,-55.82,;15.19,-53.51,;16.52,-54.28,;16.52,-55.82,;17.85,-56.59,;19.19,-55.83,;19.19,-54.28,;17.86,-53.51,;17.87,-51.98,;16.53,-51.21,;16.53,-49.66,;17.86,-48.89,;17.86,-47.35,;19.2,-49.66,;20.53,-48.88,;19.2,-51.21,)| Show InChI InChI=1S/C20H18Cl2F2N4O2.C4H6O6/c1-28-18(13(21)8-26-28)12-7-17(30-19(12)22)20(29)27-16-9-25-5-4-11(16)10-2-3-14(23)15(24)6-10;5-1(3(7)8)2(6)4(9)10/h2-3,6-8,11,16,25H,4-5,9H2,1H3,(H,27,29);1-2,5-6H,(H,7,8)(H,9,10)/t11-,16+;1-,2-/m01/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human SGK by mobility shift assay |
J Med Chem 62: 7264-7288 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00891 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase (P70S6K)
(Homo sapiens (Human)) | BDBM50528415
(CHEMBL4457064)Show SMILES O[C@H]([C@@H](O)C(O)=O)C(O)=O.Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1 |r,wU:26.26,wD:1.0,2.2,31.33,(23.87,-52,;23.87,-53.52,;25.19,-54.29,;25.19,-55.81,;26.51,-53.52,;27.84,-54.29,;26.51,-52,;22.55,-54.29,;21.23,-53.52,;22.55,-55.81,;7.85,-50.48,;7.53,-51.98,;6.12,-52.61,;6.28,-54.14,;7.78,-54.46,;8.41,-55.87,;8.56,-53.13,;10.09,-52.98,;11.12,-54.12,;12.52,-53.5,;12.37,-51.97,;10.87,-51.64,;10.24,-50.24,;13.85,-54.28,;13.85,-55.82,;15.19,-53.51,;16.52,-54.28,;16.52,-55.82,;17.85,-56.59,;19.19,-55.83,;19.19,-54.28,;17.86,-53.51,;17.87,-51.98,;16.53,-51.21,;16.53,-49.66,;17.86,-48.89,;17.86,-47.35,;19.2,-49.66,;20.53,-48.88,;19.2,-51.21,)| Show InChI InChI=1S/C20H18Cl2F2N4O2.C4H6O6/c1-28-18(13(21)8-26-28)12-7-17(30-19(12)22)20(29)27-16-9-25-5-4-11(16)10-2-3-14(23)15(24)6-10;5-1(3(7)8)2(6)4(9)10/h2-3,6-8,11,16,25H,4-5,9H2,1H3,(H,27,29);1-2,5-6H,(H,7,8)(H,9,10)/t11-,16+;1-,2-/m01/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human P70S6K by mobility shift assay |
J Med Chem 62: 7264-7288 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00891 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase AKT
(Homo sapiens (Human)) | BDBM50528415
(CHEMBL4457064)Show SMILES O[C@H]([C@@H](O)C(O)=O)C(O)=O.Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1 |r,wU:26.26,wD:1.0,2.2,31.33,(23.87,-52,;23.87,-53.52,;25.19,-54.29,;25.19,-55.81,;26.51,-53.52,;27.84,-54.29,;26.51,-52,;22.55,-54.29,;21.23,-53.52,;22.55,-55.81,;7.85,-50.48,;7.53,-51.98,;6.12,-52.61,;6.28,-54.14,;7.78,-54.46,;8.41,-55.87,;8.56,-53.13,;10.09,-52.98,;11.12,-54.12,;12.52,-53.5,;12.37,-51.97,;10.87,-51.64,;10.24,-50.24,;13.85,-54.28,;13.85,-55.82,;15.19,-53.51,;16.52,-54.28,;16.52,-55.82,;17.85,-56.59,;19.19,-55.83,;19.19,-54.28,;17.86,-53.51,;17.87,-51.98,;16.53,-51.21,;16.53,-49.66,;17.86,-48.89,;17.86,-47.35,;19.2,-49.66,;20.53,-48.88,;19.2,-51.21,)| Show InChI InChI=1S/C20H18Cl2F2N4O2.C4H6O6/c1-28-18(13(21)8-26-28)12-7-17(30-19(12)22)20(29)27-16-9-25-5-4-11(16)10-2-3-14(23)15(24)6-10;5-1(3(7)8)2(6)4(9)10/h2-3,6-8,11,16,25H,4-5,9H2,1H3,(H,27,29);1-2,5-6H,(H,7,8)(H,9,10)/t11-,16+;1-,2-/m01/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of Akt3 (unknown origin) by mobile shift assay |
J Med Chem 62: 7264-7288 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00891 |
More data for this Ligand-Target Pair | |