BDBM50528433 CHEMBL4524940

SMILES: Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CN[C@H](CCN2CCCCC2)C[C@H]1c1ccc(Cl)c(Cl)c1

InChI Key: InChIKey=RGNMNSBXVULCGF-IEGUWTFLSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50528433   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50528433 (CHEMBL4524940) Show SMILES Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CN[C@H](CCN2CCCCC2)C[C@H]1c1ccc(Cl)c(Cl)c1 |r,wU:16.17,19.21,wD:29.33,(32.6,-37.45,;32.28,-38.96,;30.87,-39.58,;31.03,-41.12,;32.53,-41.44,;33.16,-42.85,;33.31,-40.11,;34.84,-39.95,;35.87,-41.09,;37.28,-40.47,;37.12,-38.94,;35.62,-38.62,;34.99,-37.21,;38.62,-41.25,;38.61,-42.79,;39.95,-40.48,;41.28,-41.25,;41.28,-42.79,;42.61,-43.56,;43.95,-42.8,;45.28,-43.57,;46.61,-42.81,;47.94,-43.58,;47.93,-45.12,;49.25,-45.89,;50.59,-45.13,;50.6,-43.59,;49.27,-42.81,;43.95,-41.25,;42.62,-40.49,;42.62,-38.95,;41.29,-38.18,;41.29,-36.64,;42.62,-35.87,;42.61,-34.33,;43.95,-36.63,;45.28,-35.86,;43.96,-38.18,)| Show InChI InChI=1S/C27H31Cl4N5O2/c1-35-25(22(30)14-33-35)19-13-24(38-26(19)31)27(37)34-23-15-32-17(7-10-36-8-3-2-4-9-36)12-18(23)16-5-6-20(28)21(29)11-16/h5-6,11,13-14,17-18,23,32H,2-4,7-10,12,15H2,1H3,(H,34,37)/t17-,18+,23-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human Akt1 expressed in Escherichia coli using STK Substrate 2-biotin as substrate incubated for 1 hr by HTRF assay				J Med Chem 62: 7264-7288 (2019) Article DOI: 10.1021/acs.jmedchem.9b00891
					More data for this Ligand-Target Pair