BDBM50528466 CHEMBL4447158

SMILES: Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CN[C@H](CC(=O)NC2CCC2)C[C@H]1c1ccc(Cl)c(Cl)c1

InChI Key: InChIKey=VCWNNVVPOOSACP-CKJXQJPGSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50528466   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50528466 (CHEMBL4447158) Show SMILES Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CN[C@H](CC(=O)NC2CCC2)C[C@H]1c1ccc(Cl)c(Cl)c1 |r,wU:16.17,19.21,wD:29.33,(8.88,-41.02,;8.56,-42.52,;7.15,-43.15,;7.31,-44.68,;8.81,-45,;9.44,-46.41,;9.59,-43.67,;11.12,-43.51,;12.15,-44.66,;13.56,-44.04,;13.4,-42.5,;11.89,-42.18,;11.27,-40.77,;14.9,-44.81,;14.89,-46.35,;16.23,-44.04,;17.56,-44.82,;17.56,-46.35,;18.89,-47.13,;20.23,-46.36,;21.56,-47.13,;22.89,-46.37,;22.9,-44.83,;24.22,-47.14,;25.56,-46.38,;27.05,-46.79,;27.45,-45.3,;25.96,-44.9,;20.23,-44.81,;18.9,-44.05,;18.9,-42.52,;17.57,-41.75,;17.57,-40.2,;18.9,-39.43,;18.89,-37.89,;20.23,-40.2,;21.56,-39.42,;20.24,-41.75,)| Show InChI InChI=1S/C26H27Cl4N5O3/c1-35-24(20(29)11-32-35)17-10-22(38-25(17)30)26(37)34-21-12-31-15(9-23(36)33-14-3-2-4-14)8-16(21)13-5-6-18(27)19(28)7-13/h5-7,10-11,14-16,21,31H,2-4,8-9,12H2,1H3,(H,33,36)(H,34,37)/t15-,16-,21+/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human Akt1 expressed in Escherichia coli using STK Substrate 2-biotin as substrate incubated for 1 hr by HTRF assay				J Med Chem 62: 7264-7288 (2019) Article DOI: 10.1021/acs.jmedchem.9b00891
					More data for this Ligand-Target Pair