null

SMILES: Nc1nc2[nH]cc(Cc3ccc(\C=C\c4ccccc4C(O)=O)cc3)c2c(=O)[nH]1

InChI Key: InChIKey=QXLUOILIYGLPRE-MDZDMXLPSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50528938   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Polyunsaturated fatty acid lipoxygenase ALOX15B (Rattus norvegicus)	BDBM50528938 (CHEMBL4551599) Show SMILES Nc1nc2[nH]cc(Cc3ccc(\C=C\c4ccccc4C(O)=O)cc3)c2c(=O)[nH]1 Show InChI InChI=1S/C22H18N4O3/c23-22-25-19-18(20(27)26-22)16(12-24-19)11-14-7-5-13(6-8-14)9-10-15-3-1-2-4-17(15)21(28)29/h1-10,12H,11H2,(H,28,29)(H4,23,24,25,26,27)/b10-9+	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibition of recombinant human His6-tagged TS using dUMP and 5,10-methylenetetrahydrofolate as substrate by spectrometry				Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111673
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM50528938 (CHEMBL4551599) Show SMILES Nc1nc2[nH]cc(Cc3ccc(\C=C\c4ccccc4C(O)=O)cc3)c2c(=O)[nH]1 Show InChI InChI=1S/C22H18N4O3/c23-22-25-19-18(20(27)26-22)16(12-24-19)11-14-7-5-13(6-8-14)9-10-15-3-1-2-4-17(15)21(28)29/h1-10,12H,11H2,(H,28,29)(H4,23,24,25,26,27)/b10-9+	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibition of recombinant Cryptosporidium hominis TS-DHFR expresssed in Escherichia coli PA414 using dUMP and 5,10-methylenetetrahydrofolate as subst...				Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111673
					More data for this Ligand-Target Pair