BDBM50529422 CHEMBL4447753

SMILES: Cc1ccccc1CN1CCN(CC1)c1cn[nH]c(=O)c1Br

InChI Key: InChIKey=NIGSHUCAVVQZLX-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50529422   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor protein 5 (TRPC5) (Homo sapiens (Human))	BDBM50529422 (CHEMBL4447753) Show SMILES Cc1ccccc1CN1CCN(CC1)c1cn[nH]c(=O)c1Br Show InChI InChI=1S/C16H19BrN4O/c1-12-4-2-3-5-13(12)11-20-6-8-21(9-7-20)14-10-18-19-16(22)15(14)17/h2-5,10H,6-9,11H2,1H3,(H,19,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Goldfinch Bio Inc. Curated by ChEMBL					Assay Description Inhibition of lanthanum-activated human TRPC5 channel expressed in HEK293 cells measured at holding potential of -60 mV by Q-patch clamp assay				ACS Med Chem Lett 10: 1579-1585 (2019) Article DOI: 10.1021/acsmedchemlett.9b00430
					More data for this Ligand-Target Pair
Transient receptor protein 5 (TRPC5) (Homo sapiens (Human))	BDBM50529422 (CHEMBL4447753) Show SMILES Cc1ccccc1CN1CCN(CC1)c1cn[nH]c(=O)c1Br Show InChI InChI=1S/C16H19BrN4O/c1-12-4-2-3-5-13(12)11-20-6-8-21(9-7-20)14-10-18-19-16(22)15(14)17/h2-5,10H,6-9,11H2,1H3,(H,19,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Goldfinch Bio Inc. Curated by ChEMBL					Assay Description Inhibition of rosiglitazone-activated human TRPC5 channel expressed in HEK293 cells assessed as reduction in Ca2+ current measured at +80 mV with hol...				ACS Med Chem Lett 10: 1579-1585 (2019) Article DOI: 10.1021/acsmedchemlett.9b00430
					More data for this Ligand-Target Pair
Transient receptor protein 5 (TRPC5) (Homo sapiens (Human))	BDBM50529422 (CHEMBL4447753) Show SMILES Cc1ccccc1CN1CCN(CC1)c1cn[nH]c(=O)c1Br Show InChI InChI=1S/C16H19BrN4O/c1-12-4-2-3-5-13(12)11-20-6-8-21(9-7-20)14-10-18-19-16(22)15(14)17/h2-5,10H,6-9,11H2,1H3,(H,19,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Goldfinch Bio Inc. Curated by ChEMBL					Assay Description Inhibition of (-)-Englerin-activated human TRPC5 channel expressed in HEK293 cells measured at holding potential of -60 mV by Q-patch clamp assay				ACS Med Chem Lett 10: 1579-1585 (2019) Article DOI: 10.1021/acsmedchemlett.9b00430
					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM50529422 (CHEMBL4447753) Show SMILES Cc1ccccc1CN1CCN(CC1)c1cn[nH]c(=O)c1Br Show InChI InChI=1S/C16H19BrN4O/c1-12-4-2-3-5-13(12)11-20-6-8-21(9-7-20)14-10-18-19-16(22)15(14)17/h2-5,10H,6-9,11H2,1H3,(H,19,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Goldfinch Bio Inc. Curated by ChEMBL					Assay Description Inhibition of OAG-activated human TRPC6 channel expressed in HEK293 cells by Q-patch clamp assay				ACS Med Chem Lett 10: 1579-1585 (2019) Article DOI: 10.1021/acsmedchemlett.9b00430
					More data for this Ligand-Target Pair
Transient receptor protein 5 (TRPC5) (Homo sapiens (Human))	BDBM50529422 (CHEMBL4447753) Show SMILES Cc1ccccc1CN1CCN(CC1)c1cn[nH]c(=O)c1Br Show InChI InChI=1S/C16H19BrN4O/c1-12-4-2-3-5-13(12)11-20-6-8-21(9-7-20)14-10-18-19-16(22)15(14)17/h2-5,10H,6-9,11H2,1H3,(H,19,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Goldfinch Bio Inc. Curated by ChEMBL					Assay Description Inhibition of riluzole-activated human TRPC5 channel expressed in HEK293 cells measured at holding potential of -60 mV by Q-patch clamp assay				ACS Med Chem Lett 10: 1579-1585 (2019) Article DOI: 10.1021/acsmedchemlett.9b00430
					More data for this Ligand-Target Pair