BDBM50529442 CHEMBL4458766

SMILES: Cn1ncc2cccc(CN3CCN(CC3=O)c3cn[nH]c(=O)c3Cl)c12

InChI Key: InChIKey=KLZVSLPAAMLVTO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50529442   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor protein 5 (TRPC5) (Homo sapiens (Human))	BDBM50529442 (CHEMBL4458766) Show SMILES Cn1ncc2cccc(CN3CCN(CC3=O)c3cn[nH]c(=O)c3Cl)c12 Show InChI InChI=1S/C17H17ClN6O2/c1-22-16-11(7-20-22)3-2-4-12(16)9-24-6-5-23(10-14(24)25)13-8-19-21-17(26)15(13)18/h2-4,7-8H,5-6,9-10H2,1H3,(H,21,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Goldfinch Bio Inc. Curated by ChEMBL					Assay Description Inhibition of rosiglitazone-activated human TRPC5 channel expressed in HEK293 cells assessed as reduction in Ca2+ current measured at +80 mV with hol...				ACS Med Chem Lett 10: 1579-1585 (2019) Article DOI: 10.1021/acsmedchemlett.9b00430
					More data for this Ligand-Target Pair