BDBM50529446 CHEMBL4436512

SMILES: C[C@H]1CN(Cc2ccccc2C)CCN1c1cn[nH]c(=O)c1Br

InChI Key: InChIKey=HJKQOMMTUDYNHY-ZDUSSCGKSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50529446   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor protein 5 (TRPC5) (Homo sapiens (Human))	BDBM50529446 (CHEMBL4436512) Show SMILES C[C@H]1CN(Cc2ccccc2C)CCN1c1cn[nH]c(=O)c1Br |r| Show InChI InChI=1S/C17H21BrN4O/c1-12-5-3-4-6-14(12)11-21-7-8-22(13(2)10-21)15-9-19-20-17(23)16(15)18/h3-6,9,13H,7-8,10-11H2,1-2H3,(H,20,23)/t13-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Goldfinch Bio Inc. Curated by ChEMBL					Assay Description Inhibition of rosiglitazone-activated human TRPC5 channel expressed in HEK293 cells assessed as reduction in Ca2+ current measured at +80 mV with hol...				ACS Med Chem Lett 10: 1579-1585 (2019) Article DOI: 10.1021/acsmedchemlett.9b00430
					More data for this Ligand-Target Pair