BDBM50531820 CHEMBL4531582

SMILES: CC(C)C[C@H](NC(=O)N1CCC(CC1)NC(=O)Nc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1

InChI Key: InChIKey=LVHLMASEYRCPAP-CQMLEQORSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50531820   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
20S proteasome (Homo sapiens (Human))	BDBM50531820 (CHEMBL4531582) Show SMILES CC(C)C[C@H](NC(=O)N1CCC(CC1)NC(=O)Nc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C37H51ClN6O6/c1-23(2)19-29(32(45)37(5)22-50-37)41-34(47)31(21-25-9-7-6-8-10-25)42-33(46)30(20-24(3)4)43-36(49)44-17-15-28(16-18-44)40-35(48)39-27-13-11-26(38)12-14-27/h6-14,23-24,28-31H,15-22H2,1-5H3,(H,41,47)(H,42,46)(H,43,49)(H2,39,40,48)/t29-,30-,31-,37+/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Hangzhou Institute of Innovative Medicine Curated by ChEMBL					Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition				Eur J Med Chem 164: 602-614 (2019) Article DOI: 10.1016/j.ejmech.2018.12.064
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